| 摘要 |
<p>NEW MATERIAL:The compound of formula I [R1 is lower alkyl; A is group of formula II-IV (R2 is lower alkyl; R3 is lower alkyl or hydroxy-lower alkyl; R4 is lower alkyl, hydroxy-lower alkyl or carbamoyl-lower alkyl; R5 is H or hydroxy-lower alkyl), etc.]or its salt. EXAMPLE:7beta-[2-(5-Amino-1,2,4-thiadiazol-3-yl, -(Z)-2-methoxy- iminoacetamido]-3-[(E)-3-[(1R-carbamoyl-2-hydroxyethyl)dimethyl-ammoni o]-1- propenyl]-3-cephem-4-carboxylate. USE:An antibacterial agent effective against Gram-negative bacteria and Gram-positive bacteria. PREPARATION:A compound of formula V (X is halogen) is made to react with a compound of formula A' (A' is amine corresponding to A) and, as necessary, the protecting group is removed from the reaction product.</p> |
