发明名称 |
Process for preparing 4-demethoxydaunomycinone. |
摘要 |
<p>4-Demethoxy-daunomycinone I: <CHEM> the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyldaunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound, in an appropriate reducing environment, with a catalytic amount of a transition metal complex, preferably palladium or nickel with 1,3 diphenylphosphinopropane or 1,1 min -bis (diphenylphosphino) ferrocene, and eliminating the 13-dioxolanyl group by treatment with trifluoroacetic acid.</p> |
申请公布号 |
EP0337665(A2) |
申请公布日期 |
1989.10.18 |
申请号 |
EP19890303418 |
申请日期 |
1989.04.06 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
CABRI, WALTER;BERNARDINIS, SILVIA DE;FRANCALANCI, FRANCO;PENCO, SERGIO |
分类号 |
C07D317/26;B01J31/02;B01J31/24;C07B61/00;C07C45/00;C07C46/00;C07C50/38;C07C67/00;C07H15/252 |
主分类号 |
C07D317/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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