Composition for enhancing the biodistribution of antibody for localization in lesions.

摘要

A composition for use in therapy or diagnosis of lesions in a mammal, the lesions being associated with a marker substance, the composition comprising a first amount of an antibody specific for the marker and a second amount of the same or another antibody specific for the marker, wherein (a) the first amount is for initial administration to the mammal and the second amount is for subsequent administration to the mammal after at least some of the first amount has associated with the marker, one or both of the amounts including chimaeric antibodies each comprising a murine antibody region and a human antibody region, or (b) one of the said amounts of antibody is labelled with a detectable agent or a therapeutic agent and the other is unlabelled, the said two amounts being for substantially simultaneous administration to the mammal.