| 摘要 |
NEW MATERIAL:The compound of formula [R<1> is 3-8C aliphatic hydrocarbon group, 5-8C alicyclic hydrocarbon group, (alkyl-substituted) aryl, etc.; R<2> is H, 1-8C alkyl, 3-11C alkoxy, etc.; Y is O or S; Z is O or >NR<7> (R<7> is H or 1-8C aliphatic hydrocarbon group); R<3> is H, 3-11C aliphatic hydrocarbon group, etc.; R<4>-R<6> are H, 1-6C alkyl, 1-6C alkoxy, 1-6C acyl(oxy), (substituted) aryl, etc.; m and n are 0-3; m+n<=3; p is 2-10; q is 4-7]. EXAMPLE:3-Methylbutyl N-benzyl-N-(3-piperidinopropyl)carbomate. USE:A glutamic acid blocker. PREPARATION:The objective compound can be produced e.g., by adding 3- methyl-1-butanol to a benzene solution of trichloromethyl chloroformate under ice cooling to obtain a carbonyl chloride, adding an alkaline solution of 1-(3- benzylamino)propylpiperidine hydrochloride to the carbonyl chloride, collecting the benzene layer and distilling out benzene from the layer. |
