IMPROVEMENTS IN OR RELATING TO ANTIBODY PREPARATIONS

摘要

A monoclonal antibody preparation having a single binding activity, which activity is in respect of a cell surface antigen, comprises IgG antibody molecules in which only one of the two light chains will bind to said antigen, the proportion of such antibody molecules being enhanced relative to IgG antibody molecules having two light chains which will bind to said antigen to thereby produce an enhancement of the binding activity of the preparation. Such preparations containing predominatly "monovalent antibodies" are of particular value in the areas of transplantation immunity, the treatment of neoplastic disease and cell sorting.