| 摘要 |
This invention relates to isoxazolobenzoxazepines having the following formula <IMAGE> wherein X1 is H; X2 is H or OH; or X1 and X2 taken together are carbonyl oxygen or <IMAGE> R is (1) H, (2) loweralkyl, (3) arylloweralkyl, (4) loweralkynyl, (5) loweralkenyl, <IMAGE> where R1 and R2 are independently (a) H, (b) lower alkyl, (c) arylloweralkyl, (d) lower alkylene <IMAGE> where Z is H, halogen, loweralkyl, loweralkoxy, CF3, nitro or amino and n is a integer of 1 to 3; <IMAGE> where n'' is an integer of 1 to 3; or (f) R1 and R2 taken together with the nitrogen atom are substituted or unsubstituted piperidino or pyrrolidino of the formula <IMAGE> where R3 is H, loweralkyl or aryl, and m is an integer of 1 to 2; <IMAGE> (7) wherein R4is H or loweralkyl and m' is an integer of 3 to 4; <IMAGE> (8) where Z and n are as previously defined; <IMAGE> (9) where m''' is an integer of 1,2 or 3 <IMAGE>(10) where R5 and R6 are lower alkyl, aryl lower alkyl or are independently taken together with the N atom to form a substituted or unsubstituted piperidino or pyrrolidino group of the formula <IMAGE> where R3 and m are as previously defined <IMAGE> (11) where R7 is loweralkyl, aryl, or arylloweralkyl; <IMAGE> (12) where R5 and R6 are as previously defined; and the pharmaceutically acceptable acid addition salts thereof and where applicable to the geometric, stereo and optical isomers thereof.
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