THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES

摘要

This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of formula (I), wherein -YR1 is one substituent on the 5, 6, 7 or 8 position of the aromatic ring, and is -S(C1-C3) alkyl or OR1 wherein R1 is selected from the group consisting of (C1-C8) alkyl, (C1-C8) alkenyl, -CH2-(C3-C8) cycloalkyl or benzyl; wherein R2 is hydrogen or (C1-C3) alkyl; wherein R3 is -CH2-(C3-C8) cycloalkyl; wherein R4 is hydrogen, (C3-C8) alkyl, -CH2-(C3-C4) cycloalkyl-(CH2)m-R5 or -CH2-CH2-X-(CH2)nCH3; wherein n is zero to 3 and m is 2 or 3; wherein X is oxygen or sulfur; and wherein R5 is phenyl; phenyl substituted with one or two substituent groups selected from chlorine, bromine, fluorine, (C1-C3) alkoxy or (C1-C3) alkyl; 2-thiophene; or 3-thiophene; with the proviso that when R3 contains more than four carbon atoms and R4 is alkyl said alkyl contains from one to 3 carbons atoms.