Anti-human lymphotoxin monoclonal antibody, hybridoma for production thereof, anti-human lymphotoxin-C-terminal peptide antibody and method for detecting human lymphotoxin thereby.

摘要

Disclosed are a human lymphotoxin-neutralizing monoclonal antibody-producing hybridoma, an anti-human lymphonotoxin monoclonal antibody produced by that hybridoma and an anti-human lymphotoxin neutralizing antibody. The hybridoma is obtained by fusing a myeloma cell with a spleen cell or a lymphonodus cell of an animal immunized with an N-terminal-deleted human lymphotoxin. The anti-human lymphotoxin neutralizing antibody is harvested from an animal immunized with a human LT-C-terminal peptide. The two kinds of antibodies described above can be used for an immunochemical method for assaying a human lymphotoxin in a test solution, one as an antibody to be held on a carrier and the other as an antibody to be linked with a labeling agent.