| 摘要 |
Compounds useful as cholinergic drugs are disclosed which have the formula A-B and pharmaceutically acceptable salts thereof having the formula [(A-B)Q]+qM-q wherein M is a pharmaceutically acceptable anion, Q is a proton or lower alkylating group, q is as integer from 1 to 3, A is a saturated or unsaturated five- or six-membered heterocyclic moiety and B is a saturated or unsaturated five-memebered heterocyclic moiety wherein R1 and R2 are each independently hydrogen, halo, branched or straight-chain C1-C6 alkyl, branched or straight-chain C1-C6 haloalkyl, branched or straight-chain C1-C6 alkoxy, hydroxyl, keto or aryl; Y is -N= or <IMAGE> Z is -N=, <IMAGE> -O-, -S-, <IMAGE> and R3, R4 and R5 are each independently H, lower alkyl or aryl; W is -O-, -N=, or -S-; m is an integer from 1 to 5; n is an integer from 0 to 7; p is 0 or 1; and wherein, on a given molecule, when m is 2, or more, the R1's can be the same or different and two R1's can form a carbocyclic or heterocylic moiety fused onto adjacent positions of A and when p is 1, the two W's can be the same or different; and when n is 2 or more, the R2's can be the same or different and two R2's can form a carbocyclic or heterocyclic moiety fused onto adjacent positions of B. Pharmaceutical compositions useful in treating disorders of the central and peripheral nervous system of mammals, comprising an effective amounts of the aforesaid compounds, can be administered orally or intravenously.
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