5-FLUOROBENZONITRILE DERIVATIVES AND PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF FOR INCREASING THE LEAN MEAT TO FAT RATIO, AND/OR ENHANCING THE GROWTH RATE OF WARM-BLOODED ANIMALS

摘要

5-FLUOROBENZONITRILE DERIVATIVES AND PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREFOR FOR INCREASING THE LEAN MEAT TO FAT RATIO, AND/OR ENHANCING THE GROWTH RATE OF WARM-BLOODED ANIMALS There are provided novel 5-fluorobenzonitrile derivatives having the following general formula: wherein R is isopropyl or tert-butyl; and the optical isomers thereof and the non-toxic, pharmacologically acceptable acid addition salts thereof. These compounds exhibit low .beta.1 heart stimulant activity and are useful for increasing the lean meat to fat ratio and/or enhancing the growth rate of warm-blooded animals by, orally or parenterally, administering to said animals an amount of a 5-fluorobenzonitrile derivative or a pharmacologically acceptable salt thereof effective for achieving one or more of the above-identified metabolic improvements in said warm-blooded animals.