COMPOUNDS WITH HISTAMINE H2-RECEPTOR ANTAGONISTIC ACTIVITIES

摘要

Compounds of the formula (I) : (I) or pharmaceutically acceptable salts thereof, wherein : R1 and R2 are independently C1-4alkyl; or R1 and R2 together with the nitrogen atom to which they are joined represent a pyrrolidino, piperidino or hexahydroazepino ring; Y is straight-chain or branched-chain C1-4alkyl; n is 2 to 5; m is 0 or 1; when m is l, Z is inter alia an optionally substituted pyridine, pyrimidine, oxazole, thiazole, imidazole, benzoxazole benzthiazole or N-alkylbenzimidazole ring; when m is O, Z is an optionally substituted imidazole, pyrazole or benzimidazole ring. The compounds are histamine H2-receptor antagonists and are relatively lipophilic and can penetrate the blood-brain barrier and are useful in treating diseases mediated via histamine H2-receptors. Processes for their preparation, pharmaceutical compositions and methods of use are described.