[2-[2-(5-DIMETHYLAMINOMETHYLFURAN-2-YLMETHYLTHIO) -ETHYLAMINO-5-(2-METHOXYPYRID-4-YLMETHYL) PYRIMIDIM-4-ONE]

摘要

11817 A process for preparing 2-(2-(5-dimethylaminomethyl-furan-2-ylmethylthio)ethylamino)-5-(2-methoxypyrid-4-yl-methyl)pyrimidin-4-one which comprises reacting 2-(2- (furan-2-ylmethylthio)ethylamino)-5-(2-methoxypyrid-4-ylmethyl)pyrimidin-4-one with a organic solution of bis(dimethylamino)methane at a pH of about 1.3 to about 2.5. The product is an H2-antagonist and also is of value in forming 2-(2-(5-dimethylaminomethylfuran-2-yl-methylthio)ethylamino)-5-(2-hydroxypyrid-4-ylmethyl)-pyrimidin-4-one by deprotecting.