4-OXO-PYRIDO(2,3-D)PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The present invention concerns new 4-oxo-pyrido¢2,3-d!pyrimidine derivatives of the general formula I (I) wherein R1 respresents an unsubstituted or substituted aromatic or heteroaromatic ring, R2 a nitril group, a carboxyl group or an alkoxycarbonyl residue with up to 6 carbon atoms, R3 a straight-chained or branched alkyl group with up to 4 carbon atoms, or an amino group, and R4 represents hydrogen, an alkyl, alkoxyalkyl or a substi tuted or unsubstituted aminoalkyl group, the pharmacologically acceptable salts thereof, as well as processes for their preparation. The compounds of the general formula I possess valuable pharmacological properties. In particular used as calcium antagonists they exert vasospasmolytic, vasodilatory and antihypertensive acitvities. Surprisingly some of the compounds also have the effect of increasing contractility. They are therefore particularly suited for the treatment of vascular diseases.