ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF BICYCLOMYCINDERIVATER

摘要

An antibiotic WS-4545 and the acyl derivatives thereof, which are active against a pathogenic bacteria and useful as an effective antimicrobial agent in treatment of infectious diseases caused by bacteria, the antibiotic WS-4545 being produced by fermentation of Streptomyces sapporonensis ATCC 21532 and its mutants in a nutrient medium and the acyl derivatives of said antibiotic being prepared by acylating said antibiotic with an acylating agent.