4-Pentafluorophenoxypiperidines, a process for their preparation and their use as medicaments.

摘要

This invention relates to 4-pentafluorophenoxypiperidines of formula I <CHEM> wherein R<1> is hydrogen or aryl; and R is a monovalent radical selected from the group consisting of hdyrogen, cyano, loweralkyl, arylloweralkyl, bis-(aryl)loweralkyl, aminoloweralkyl, (loweralkylamino)loweralkyl, (diloweralkylamino)loweralkyl, (diloweralkylphosphinyl)loweralkyl, heteroarylloweralkyl, and a group of the formula <CHEM> wherein A is a loweralkylene, loweralkenylene or loweralkynylene, m is an integer having a value of zero or 1, W is CH2 or NR<7> wherein R<7> is hydrogen, loweralkyl or aryl, and p is an integer having a value of zero or 1, and to a process for their preparation. The compounds, alone or in combination with one ore more pharmaceutically acceptable carriers, are useful for alleviating pain, treating depression, reducing blood pressure, and treating convulsions, and can, therefore, be used as medicaments.