A DNA SEQUENCE ENCODING THE -i(ROS) ONCOGENE, POLYPEPTIDES ENCODED THEREFROM, AND DIAGNOSTIC AND OTHER METHODS BASED THEREON.

摘要

DNA sequence comprising an activated oncogene, said oncogene encoding a polypeptide capable of transforming NIH3T3 cells and of inducing a tumor when injected into nude mice, and further said polypeptide having a tyrosine-specific protein kinase activity. The invention also concerns a polypeptide molecule encoded by an activated oncogene, said molecule having the properties of transforming NIH3T3 cells, inducing a tumor when injected into nude mice and acting as a tyrosine-specific protein kinase. Finally, this invention provides a method for treating a tumor induced by an activated ros1 oncogene.