发明名称 |
PREVENTION OF PNEUMOCYSTIS CARINII PNEUMONIA USING PENTAMIDINE IN AEROZOL FORM |
摘要 |
PURPOSE: To prevent/treat pneumocystis carinii pneumonia(PCP) without any concomitant significant toxic reaction by administering pentamidine in the form of aerosol spray with specific particulate size. CONSTITUTION: A patient subject to or already affected by PCP is administered with an effective dose of pentamidine; p,p'-(pentamethylenedioxy)dibenzamidine or a pharmaceutically permissible salt thereof (e.g. isethionate) in the form of aerosol spray with particulate size being 0.5-8.0μm in aerodynamic diameter. For the aerosol spray, particulates each 0.5-8μm in diameter preferably account for >=55wt.% of the whole particulates, and the mass median aerodynamic diameter is pref. 1-6 (esp. 1-4)μ; and the aerosol spray is preferably produced by the use of an ultrasonic nebulizer. The dose of the pentamidine is 1-200 (pref. 45-75)mg for preventing PCP.
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申请公布号 |
JPH01228912(A) |
申请公布日期 |
1989.09.12 |
申请号 |
JP19880069927 |
申请日期 |
1988.03.25 |
申请人 |
SLOAN KETTERING INST CANCER RES |
发明人 |
EDOWAADO EMU BAANAADO;DONARUDO AAMUSUTORONGU |
分类号 |
A61K9/00;A61K9/12;A61K31/155;A61P31/04 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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地址 |
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