| 摘要 |
<p>A method for increasing the water-solubility of essentially insoluble pharmaceuticals by formation of complexes thereof with oligomers of N-vinyl pyrrolidone is described. Highly stable complexes of indomethacin, dapsone, furosemide and chlorhexidine were prepared and exhibited solubility increases of about 25-fold compared with the non-complexed compounds. Methods for preparing the complexes are also set forth.</p> |
