| 摘要 |
NEW MATERIAL:A peptide having an activity of inhibiting reverse transcriptase of the formula (R<1>, R<2> are residues of arbitrary 12 amino acids, either A of B is an amino acid residue bearing aromatic ring, the other is residue of arbitrary amino acid; C, E are residues of arbitrary amino acids, F is residue of amino acid bearing aromatic ring; D is residue of amino acid bearing cationic or anionic charge on its side chain; H is residue of amino acid bearing cationic charge on its side chain; G is Ala, Ser). USE:Antiviral. PREPARATION:For example, a protected amino acid is bonded to 4-(hydroxymethyl)-phenylacetamide methyl resin and the amino acid is deprotected in order in accordance with the amino acid sequence of the peptide, and the operations are repeated. After the peptide chain is synthesized, the peptide is eliminated from the resin by treatment with hydrogen fluoride or the like to remove the protecting groups. Finally, the peptide is purified by, for example, gel filtration or the like to give the subject product of the formula. |
