Chemiluminescent 9-sulphonyl-aminocarbonyl-acridinium salts

摘要

Chemiluminescent acridinium derivs. of formula (I) and their quat. ammonium derivs. are new: R1 = H; up to 10C alkyl, alkenyl or alkynyl; benzyl or aryl; R2 and R3 = H, 1-4C alkyl, amino (opt.substd.), COOH, alkoxy, CN, NO2 or halo; R4 = -N(R6)-SO2-XR5 or -N(XR5)-SO2R6; R5 = reactive gp. which, under mild conditions, can form a bond selectively with an NH2, COOH, SH or other functional gp.in a biologically interesting cpd.; R6 = H; up to 10C alkyl, alkenyl or alkoxy; substd. amino; benzyl; aryl; heteroalkyl or heterocyclyl, opt. substd. by OH; amino; alkylamino; 1-4C alkyl, alkenyl or alkoxy; polyalkoxy, aryloxy or heterocyclyl, one or more times, and these substits. may themselves be substd. by heterocyclyl or amino, or together form a heterocycle contg. at least one O, S, NH or N-alkyl; X = arylene bonded to N or S directly or via an alkylene or oxyalkylene gp., and bonded via alkylene or oxyalkylene to R5, and opt. substd. by 1 or more alkyl, alkenyl, OH, NH2, alkoxy or aryloxy gps. and/or heteroatoms; or X = residue of an aliphatic, araliphatic or aromatic aminoacid (not necessarily natural); if R6 = phenyl substd. by 1 or more 1-6C alkyl, then X can also be phenylene. A- is not defined but is an anion in all examples