| 摘要 |
A process for producing peptides and beta -lactam antibiotics from their amino acid precursors, and analogs thereof, is described. A mixture of @- alpha -aminoadipic acid (A), @-cysteine (C) and @-valine (V) is enzymatically converted into @@@-ACV by a glycerol stabilized cell free extracted of Cephalosporium acremonium (Acremonium chrysogenum ATCC48272). The cell free extract is a single enzyme defined as ACV-synthetase which requires all three @-amino acids for maximum activity. |
