THE USE OF ANELLATED COMPOUNDS AS INHIBITORS OF ERTYHROCYTE AGGREGATION

摘要

The tricyclics of the formula I …… in which R1 is an optionally substituted phenyl ring or an optionally substituted heterocyclic five-membered ring with 1 - 4 hetero atoms or a heterocyclic six-membered ring with 1 - 5 hetero atoms, where the hetero atoms can be identical or different and are oxygen, sulphur or nitrogen, and, if required, can carry an oxygen atom on one or more nitrogen atoms, or in the case where X is a bond, R1 is, besides the abovementioned groups, also a hydrogen atom, an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, halogenoalkyl, alkoxyalkyl, carboxyalkyl, alkoxyl-carbonylalkyl, a hydroxyl, mercapto, amino, alkylmercapto, formylaminoalkyl or a pyridylcarbonylamino group,… X is a bond, an alkylene or the vinylene group,… A can be a nitrogen atom or the group CR5 where R5 is a hydrogen atom, an alkyl, alkenyl, cycloalkyl, cycloalkenyl, cyano, alkylcarbonyl, alkoxycarbonyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl or aryl group,… B is an oxygen atom, a sulphur atom or the group NR6 where R6 is a hydrogen atom or an alkyl group, or B can be the group CR7R8 where R7 is a hydrogen atom, an alkyl, alkenyl or a cycloalkyl group, and R8 is a hydrogen atom, an alkyl, alkenyl or cyano group, a carbonyl group which is substituted by hydroxyl, alkyl, alkoxy, amino, alkylamino, dialkylamino or hydrazino, or R7 and R8 together form an alkylidene or cycloalkylidene group, or R7 and R8 form together with the C atom to which they are bonded a spirocycle,… and their pharmacologically tolerated salts are used for the treatment of diseases in whose pathogenesis erythrocyte aggregation plays an important part.