| 摘要 |
PCT No. PCT/NL86/00033 Sec. 371 Date Jul. 17, 1987 Sec. 102(e) Date Jul. 17, 1987 PCT Filed Oct. 3, 1986 PCT Pub. No. WO87/02135 PCT Pub. Date Apr. 9, 1987.A substrate for an apparatus for quantitative detection of a component present in a gas or liquid, in which substrate elastic vibrations can be generated, said substrate being provided with a surface layer adapted to bond said component, so that the vibration behavior of said layer is changed. At least the surface portion of said substrate consists of a substance with active sites (A) for covalent bonding situated at its free surface, to which sites (A) molecules of a substance (X) are covalently bonded which, on the other hand, possess active sites (B) for selectively and reversibly bonding by means of a coordinative bond of the molecules of the component (G) to be detected. In particular between each active site (A) of the substrate and a molecule of the component bonding substance (X) a molecule of a coupler (K) can be inserted, which is covalently bonded to an active site (A) of said substrate, and, on the other hand, is bonded by means of a second bond (C) with a molecule of the component bonding substance (X), said second bond being a substantially covalent bond or a substantially coordinative bond. The component bonding substance (X) can be a substance in the form of an inclusion compound (X1), a complexing compound (X2), a metal ion cluster (X3), or an enzyme (X4). The coupler (K) can be formed by a trialkoxysilane compound with general formula (RO)3Si(CH2)n-Y, in which Y is adapted to provide the covalent or coordinative bond (C) with the component bonding substance (X), and comprises an active group, which coupler (K) can be a compound of the following kind (Formula I).
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