Method of treating tumors using tetracyclo compounds

摘要

The invention relates to a method for treatment of carcinoma or sarcoma tumor in mammals which comprises administering to said mammal an effective amount of a tetracyclo compound of the formula: <IMAGE> in which R1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy, aryliminomethyl, hydroxyiminomethyl, alkoxyiminomethyl, acyloxyiminomethyl, semicarbazonomethyl or arylsemicarbazonomethyl, R2 is hydroxy, alkoxy, or protected hydroxy, R3 is hydrogen and R4 is methyl, hydroxymethyl or protected hydroxymethyl, or R3 and R4 are combined together to form methylene or oxo, R5 is hydroxy, alkoxy or protected hydroxy, and R6 is hydrogen, imino-protective group or alkyl, and pharmaceutically acceptable salts thereof.