| 摘要 |
PURPOSE:To conduct the isolation and purification of carnitine and carnitine amide by treating a carnitine aqueous solution containing carnitine amide with a cation-exchange resin. CONSTITUTION:A carnitine aqueous solution containing carnitine amide is brought into contact with a cation exchange resin equilibrated with an aqueous solution of 1-5pH whereby carnitine and carnitine amide are adsorbed to the resin. Then, the resin is treated with aqueous ammonia, a variety of ammonium salt and amine solutions to elute carnitine preferentially. Carnitine can be isolated by allowing carnitine amide to remain in the resin. Carnitine has L- and D-optical isomers, and L-carnitine acts as a carrier of fatty acids passing through the mitochondria membrane. Thus, the compound is used as a therapeutic agent for diseases in the cardiovascular system and nephrectopathy. |
