| 摘要 |
NEW MATERIAL:A sulfonamide compound shown by the formula (R1 is lower alkyl, lower alkoxy or halogen; R2 is H, lower alkyl, aryl or arylalkyl; R3 is aryl or arylalkyl; R4 and R4' may be the same or different and H, lower alkyl or lower alkoxy; m is 0-3; n is 1-8) and an acid addition salt thereof. EXAMPLE:1-Diphenylmethyl-4-(3-benzenesulfonylaminopropyl)piperazine. USE:Useful as a drug for cardiovascular system. PREPARATION:For example, a compound shown by formula II is reacted with a compound shown by formula III in a solvent such as methylene chloride or chloroform at -10-+100 deg.C, preferably in the presence of a base such as sodium hydroxide to give a compound shown by formula I wherein R2 is H. Further this compound is reacted with a compound shown by the formula R2'Y (R2' is R2 except H; Y is halogen, alkylsulfonyloxy, etc.) and converted to a compound shown by formula I wherein R2 is except H. |
