发明名称 |
Derivatives of 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonines and -1,4-benzoxazonines, processes for their production and their use as pharmaceuticals |
摘要 |
New 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonine and -1,4-benzoxazonine compounds of the formula <IMAGE> have useful pharmaceutical properites. They are prepared from ketones of the formula <IMAGE> via a lactone intermediate. In the formula, the various R substitutes are generally hydrogen or alkyl, with R4 also being halogen or alkoxy and R3R3' also being phenyl. R1 may be joined with R5/R5' in a 5- to 7-membered ring possibly interrupted by O, S, SO2 or amino. One of X and Y is CH2; the other is amino. The starting ketones also have pharmaceutical properties. The lactone intermediates are new compounds.
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申请公布号 |
US4859664(A) |
申请公布日期 |
1989.08.22 |
申请号 |
US19870093553 |
申请日期 |
1987.09.04 |
申请人 |
MADAUS GMBH & COMPANY |
发明人 |
EIDEN, FRIEDRICH;GMEINER, PETER;SCHUENEMANN, JUERGEN |
分类号 |
C07D223/14;A61K31/343;A61K31/55;A61P25/04;A61P29/02;C07D311/78;C07D491/08;C07D491/18;C07D493/04;C07D493/08;C07D495/04;C07D495/08;C07D495/18 |
主分类号 |
C07D223/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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