摘要 |
<CHEM> in which: W is C1-7 alkylene; X is cis or trans -CH=CH- or -CH2CH2-; n is 1 or 2; Y is a saturated heterocyclic amino group; Alk is C1-5 alkylene; l is zero or 1; m is zero, 1, 2, 3 or 4; R<1> is a hydroxyl group or a group selected from -OCOR<3>, -CO2R<3>, -CONR<3>R<4>, -SO2NR<3>R<4>, -NHCOR<3>, -NHSO2R<5>, -SO2R<5>, -SR<5>, -NR<3>R<4>, -COR<5>, -NHCONR<3>R<4> and -NHCSNH2; and -COR<2> is an acid, ester, thioester or amide group; including their salts, solvates and cyclodextrin complexes. These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic or antiasthmatic agent. |