PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 3-AMINOCARBOXYLIC ACIDS (ESTERS)

摘要

Process for the production of an optically active 3-aminocarboxylic acid ester from a beta -keto acid ester. The beta -keto acid ester is converted with a chiral amine into the corresponding enamine. The enamine is converted by hydrogenation in the presence of a platinum catalyst into the corresponding N-substituted amino acid esters. Such ester mix is converted by means of HCl gas into the hydrochlorides. The latter are neutralized. Then by liberation and isolation from the neutralized products by hydrogenolysis in the presence of a palladium catalyst, the desired optically-active 3-aminocarboxylic acid ester is obtained.