| 摘要 |
<p>A polypeptide immunogen is provided which polypeptide stimulates the production of neutralizing antibody to rotavirus strains. The polypeptide comprises an epitope of a conserved region of rhesus rotavirus (RRV) VP3 or VP7 protein. Usually the polypeptide comprises at least 10 amino acides having substantially the same amino acid sequence as consecutive amino acids within residues 75 to 200 or 370 to 490 of VP3 or residues 75 to 250 of VP7. DNA fragments and expression constructs encoding the polypeptides are also provided, together with vaccines and methods of protecting a susceptible host animal from rotavirus infection.</p> |
