| 摘要 |
<p>The present invention relates to novel genes for the expression of proteins. These genes enable the expression of proteins which are normally retained within a cell to either be exported from the cell or bound to the cell membrane of the cell. In addition, novel genes are provided for the expression of proteins, which are naturally exported from the cell, bound to the cell membrane. The novel genes of the present invention are particularly useful in the expression of antigens of rotavirus and particularly to rotavirus VP7 protein which is normally retained in the endoplasmic reticulum of the cell. By enabling the expression of proteins such as rotavirus VP7 protein on the cell membrane or in a form exported from the cell an advantageous method is provided for obtaining this antigen for use in vaccines.</p> |
