PROCESS FOR THE PRODUCTION OF ARYLAMINO-NITRO-PHENYL-HYDROXYETHYL SULPHONES

摘要

1. A process for the preparation of arylaminonitrophenyl hydroxyethyl sulfones of the formula (1) see diagramm : EP0213485,P8,F1 in which Z denotes the radical see diagramm : EP0213485,P8,F2 (Za ) or see diagramm : EP0213485,P8,F3 (Zb ) in which R represents a hydrogen atom or a C1 -C4 -alkyl group, R1 denotes an -NH-R group, R2 denotes a hydrogen atom, a C1 -C4 -alkyl group of a C1 -C4 -alkoxy group, R3 represents a hydrogen, chlorine or bromine atom or a sulfonic acid, sulfonamide, carboxylic acid, carboxamide, hydroxyl, carbomethoxy, carboethoxy or beta-hydroxyethylsulfonyl group, R4 denotes a hydrogen, chlorine or bromine atom or a sulfonic acid, carboxylic acid, hydroxyl or C1 -C4 -alkoxy or C1 -C4 -alkyl group, it being possible for 1-3 different R1 -R3 substituents, not more than two of which may, however, be identical, to be present in the radical Za , but for 1-4 different R1 -R4 substituents, not more than two of which may, however, be identical, to be present in the radical Zb , and R has the meaning mentioned earlier in the text, which comprises reacting compounds of the formula (2) see diagramm : EP0213485,P8,F4 in which X denotes a chlorine or bromine atom, with a diamino compound of the formula see diagramm : EP0213485,P8,F5 or see diagramm : EP0213485,P8,F6 in which R, R1 , R2 , R3 and R4 have the meanings mentioned above, at temperatures from 20 to 180 degrees C, preferably in water at pH values from 4.0 to 10.0 or in suitable organic solvents or mixtures of such solvents, in the presence of an inorganic or organic acid-binding agent.