| 摘要 |
The present invention relates to a pharmaceutical composition containing diltiazem as a therapeutically active ingredient and to be administered in the form of a multiple-unit-dose granule formulation once and/or twice a day, wherein a diltiazem acid addition salt is administered partly in the form of an uncoated multiple-unit-dose granule, and partly in the form of a multiple-unit-dose granule being coated with a mixture of ethyl cellulose and an anionic polymer which dissolves at a pH of above 5.0 and whereby said composition releases and whereby the coating mixture contains 20-40 parts per weight of anionic polymer in relation to 80-60 parts per weight of ethyl cellulose. |
