| 摘要 |
NEW MATERIAL:A cyclocondensation quinone derivative shown by formula I (R<1>, R<2> and R<3> are H, methyl or methoxy; R<4> is hydroxymethyl or carboxyl which may be amidated or esterified; X is H, halogen, lower alkyl or methoxy; Y is CH2 or O) or a hydroquinone derivative thereof. EXAMPLE:1,2,3,4-Tetrahydro-4-(3,4-dimethoxy-6-methyl-2,5-benzoquinonyl )-2- naphthoic acid. USE:A drug useful for improving and treating diseases based on organic disorder in the brain. A small of the drug is orally administered. Low toxicity. PREPARATION:For example, a substituted benzaldehyde is reacted with succinic anhydride to give a butyrolactonecarboxylic acid derivative shown by formula II, which is esterified, reduced and then subjected to ring closure to give a tetralone derivative shown by formula IV. This derivative is reduced and treated with a dehydrating condensation agent to give a lactone shown by formula VI, which is condensed with a hydroquinone derivative shown by formula VII to give a compound shown by formula I wherein Y=CH2. |
