发明名称 |
Vaccine containing polypeptides derived from the envelope gene of human immunodeficiency virus type 1. |
摘要 |
<p>An Acquired Immunodeficiency Syndrome (AIDS) vaccine containing the Human Immunodeficiency Virus, Type-1 (HIV-1) envelope proteins is produced from cloned HIV-1 envelope genes in a baculovirus-inset cell vector system. The recombinant HIV-1 proteins are purified, assembled into particles and then adsorbed on an aluminum phosphate adjuvant. The resulting adsorbed recombinant HIV-1 virus envelope protein formulation is highly immunogenic in animals and elicits antibodies which bind to the HIV-1 virus envelope and neutralize the infectivity of the virus in in vitro tests.</p> |
申请公布号 |
EP0327180(A2) |
申请公布日期 |
1989.08.09 |
申请号 |
EP19890200230 |
申请日期 |
1989.02.02 |
申请人 |
MICROGENESYS, INC. |
发明人 |
SMITH, GALE E.;COCHRAN, MARK A.;VOLVOVITZ, FRANKLIN |
分类号 |
C12N15/09;A61K38/00;A61K39/00;A61K39/21;A61P31/12;A61P31/18;C07K1/22;C07K14/00;C07K14/005;C07K14/155;C07K14/16;C07K14/195;C07K14/705;C12N15/866;C12P21/02;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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