发明名称 |
Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia. |
摘要 |
<p>The present invention provides pyrazines, pyridazines or pyrimidines, or salts or prodrugs thereof, substituted on one of the ring carbon atoms therefore with a non-aromatic azacyclic or azabicyclic ring system; and independently substituted on each of the other ring carbon atoms with a substituent of low lipophilicity or a hydrocarbon substituent; which compounds stimulate central muscarinic acetylcholine receptors and therefore are useful in the treatment of neurological and mental illnesses.</p> |
申请公布号 |
EP0327155(A2) |
申请公布日期 |
1989.08.09 |
申请号 |
EP19890200147 |
申请日期 |
1989.01.23 |
申请人 |
MERCK SHARP & DOHME LTD. |
发明人 |
BAKER, RAYMOND;SAUNDERS, JOHN;STREET, LESLIE J. |
分类号 |
C07D401/04;A61K31/495;A61P25/00;A61P25/02;C07D403/04;C07D403/12;C07D451/02;C07D453/02;C07D453/06;C07D471/08;C07D487/04;C07D487/08 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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