PROCESS FOR THE PREPARATION OF AMINO GLYCOCIDE ANTIBIOTICS DERIVATIVES

摘要

The method of preparing aminoglycocide antibiotics comprises: (a) dissolving 1.46g of 2-hydroxyimino-2-phenylacetonitril in 20ml of tetrahydropyran at room temp; (b) adding 1.4ml of triethylamine to the mixture; (c) mixing 1.86g of diethylchlorophosphate with the above mixture for 4 hrs; (d) filtering the mixture and concentrating the resulting solution.