PREPARATION OF 1-(CARBAMOYL)-N-(CARBAMOYLOXY)-THIOFORMIMIDATES FROM ACETOACETAMIDES

摘要

1-(Carbamoyl)-N-(carbamoyloxy)thioformimidates such as methyl 1-(carbamoyl)-N-methylcarbamoyloxy)thioformimidate and methyl 1-(dimethylcarbamoyl)-N-(methylcarbamoyloxy)thioformimidate are prepared by the steps of A. REACTING DIKETENE WITH AMMONIA OR AN AMINE TO OBTAIN AN ACETOACETAMIDE; B. REACTING THE PRODUCT OF (A) WITH A NITROSATING AGENT IN THE PRESENCE OF WATER OR AN ALCOHOL; C. CHLORINATING THE PRODUCT OF (B) AT A TEMPERATURE OF -10 TO 75 DEG C.