发明名称 |
Renin inhibitory oligopeptides, their preparation and use. |
摘要 |
<p>Compounds of formula (I): <CHEM> [in which: A is a carbon-carbon bond or C1 - C3 alkylene; B is imino group or C1 - C2 alkylene; R<1> is C1 - C4 alkyl, C1 - C4 alkoxy, heterocyclic or optionally substituted amino; R<2> is optionally substituted phenyl or optionally substituted naphthyl; R<3> is thiazolyl, isoxazolyl or imidazolyl; R<4> is isopropyl or cyclohexyl; R<5> and R<6> are C1 - C4 alkyl, or, together with the carbon atom to which they are attached, C3 - C7 cycloalkyl; R<7> is hydrogen or optionally substituted C1 - C6 alkyl; and R<8> is hydrogen or C1 - C4 alkyl] have renin-inhibitory and, hence, hypotensive activities and are of value in the diagnosis and treatment of hypertension induced by failures in the renin-angiotensin system. They may be prepared by reacting together appropriate amino acids, lower oligopeptides or derivatives thereof.</p> |
申请公布号 |
EP0326364(A2) |
申请公布日期 |
1989.08.02 |
申请号 |
EP19890300717 |
申请日期 |
1989.01.25 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
MORISAWA, YASUHIRO SANKYO COMPANY LIMITED;KATAOKA, MITSURU SANKYO COMPANY LIMITED;YABE, YUICHIRO SANKYO COMPANY LIMITED;KOIKE, HIROYUKI SANKYO COMPANY LIMITED;TAKAHAGI, HIDEKUNI SANKYO COMPANY LIMITED;IIJIMA, YASUTERU SANKYO COMPANY LIMITED;KOKUBU, TATSUO SANKYO COMPANY LIMITED;HIWADA, KUNIO SANKYO COMPANY LIMITED |
分类号 |
C07K5/02 |
主分类号 |
C07K5/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|