发明名称 |
Concentrated solutions of corticosteroids and method of making them. |
摘要 |
A solution of a corticosteroid comprising: at least about 2,5 % of the corticosteroid; from about 25 % to about 80 % of a surfactant; from about 0 to about 70 % ethanol; from about 0 to about 70 % propylene glycol; provided that the amount of ethanol or of propylene glycol or of the two together is at least about 15 %; an effective amount of an antimicrobial agent; and remainder water. Also, a method of preparing this solution comprising: mixing the surfactant and the corticosteroid with heating until the temperature is from about 5 to about 10 DEG C above the pour point of the surfactant; separately mixing the remaining ingredients with heating until the temperature is from about 5 to about 10 DEG C above the pour point of the surfactant; combining the two mixtures; and heating the combined mixtures at a temperature from about 5 to about 10 DEG C above the pour point of the surfactant with mixing until a solution is formed.
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申请公布号 |
EP0325949(A1) |
申请公布日期 |
1989.08.02 |
申请号 |
EP19890100413 |
申请日期 |
1989.01.11 |
申请人 |
SCHWARZ PHARMA AG |
发明人 |
MULTHAUF, DONNA K. C/O SCHWARZ PARMA-KREMERS;WAGLE, SUDHAKAR S., DR. C/O SCHWARZ PARMA-KREMERS |
分类号 |
A61K9/00;A61K31/57;A61K47/10;A61K47/26 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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