DIHYDROPYRIDINE DERIVATIVES,PROCESS AND NOVEL INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Novel dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula: …… or a pharmaceutically acceptable acid addition salt thereof, wherein… n is an integer from 0 to 8;… Y is -O-, -NH-, -NR2-, -S-, -S(O)-, -S(O)2-, or a bond;… R1 and R2 are each independently, A1, A2, A3 or A4 where A1 is -(CH2)m(CHOH)pCH2OH;… A2 is -(CH2)qCH(3-r)[(CH2)sOH]r;… A3 is -(CH2)qCH(3-r)[(CH2)PCOOR3]r; and… A4 is -(CH2)mCOOR3; where… m is an integer from 1 to 8;… p is an integer from 0 to 4;… q is an integer from 0 to 8;… r is 2 or 3;… s is an integer from 1 to 4; and… R3 is H or alkyl of 1 to 18 carbon atoms;… R4 is -NO2, -CF3, or halo; and… R5 is lower alkyl or -CH2CH2OCH3.