| 摘要 |
<p>Hentetracontapeptide CRF and its derivatives are used in pharmaceutical treatment for mammals. I-R1-Pro-Pro-Ile-Ser-R8-Asp - Leu-R11-R12-R13-Leu-Leu-Arg-R17-R18-R19-Glu-R21-R22-Lys-R24-R25-R26- R27-R28-Gln-Gln-Ala-R32-R33-Asn-Arg-R36-Leu-Leu-Asp-R40-R41NH2. In above structure, Z=H or (C1-7) acyl; R1=ser-Gln-Glu or pGlu-Gly or Gln-Glu; R8, R12, R19, R24 and R40=Leu, Ile, Ala, Gly, Val, Nle, Phe and Gln; R11=Thr or Ser; R13=His, Tyr or glu; R17=Glu or Lys; R18=Val or Met; R21=Met, Ile, Ala, Leu or gln; R22=Thr or Glu; R25=Asp or glu; R26=Gln or Lys; R29=Leu, Ile, Ala or Glu; R28=Ala or Lys; R32=His, Tyr or Ala; R33=Ser, Asn or Ala; R36=Lys or Leu; R41=Ala, Ile, Gly, Val, sLeu, Nle, Phe, Gln or desR41.</p> |
