| 摘要 |
<p>The present invention includes compounds represented by formula (I), wherein n is 0 or 1; R1, R2, R3 and R4 are independently selected from hydrogen, hydroxyl, amino, alkylamino, alkylsulfonylamino, loweralkyl, loweralkoxy, halo, and thioalkoxy; R1 and R2 or R2 and R3 taken together can form a methylenedioxy or ethylenedioxy bridge; R10 is independently selected from hydrogen, loweralkyl, phenyl, and substituted phenyl; R5 is loweralkyl; R9 is hydrogen or loweralkyl; R6 and R8 are hydrogen; and R7 is (II), wherein m is 0, 1 or 2; X is CH2, O, S or N-CH3; or R7 is (III), wherein s is 0, 1, or 2; Z is C or N; R11 and R12 are independently selected from hydrogen, halo, hydroxy, methoxy, thiomethoxy, amino and loweralkyl, or R11 and R12 taken together can form a methylenedioxy or ethylenedioxy bridge; or R7 is (IV), wherein t is 0 or 1; or R5 and R9 taken together form a pyrrolidine ring and then R6 and R8 are hydrogen and R7 is as described above; or R5 and R9 taken together form a pyrrolidine ring and then R6 is hydrogen and R7 and R8 taken together may form a phenyl, substituted phenyl, thienyl or furyl ring; or R5 and R8 taken together form a pyrrolidine ring and then R9 and R6 are hydrogen and R7 is phenyl, substituted phenyl, thienyl, or furyl; or R7 and R9 are hydrogen and R6 is benzyl, substituted benzyl, thienylmethyl, or furylmethyl; or a pharmaceutically acceptable salt thereof.</p> |
