PROCESS FOR THE SYNTHESIS OF 1-SUBSTITUTED IMIDAZOLE-5-CARBOXYLIC ACIDS AND CARBOXYLIC ACID DERIVATIVES

摘要

1,5-Disubstituted imidazoles of the formula …… are prepared by alkylation of an N-cyanoformamidine of the formula II X - NH - CH = N - CN     (II)… to give an N,N-disubstituted N-cyanoformamidine of the formula …… which cyclises by the action of a base to give a 4-aminoimidazole of the formula …… which is then reduced to the product of the formula I.