发明名称 DIAGNOSTIC PROBE FOR DIABETES TYPE 1 PREDISPOSITION
摘要 <p>An oligonucleotide probe capable of specifically hybridizing with the gene sequence 3 min -GCGGGCRARGRGGGGGRGCAG-5 min or 5 min -CGCCCGATACACCCCCACGTC-3 min wherein A is adenine, C is cytosine, G is guanine, T is thymine, and R is thymine or uracil. The probe may include at least 15 sequential nucleotides selected from the sequence 5 min -GCCCGATACACCCCCACGT-3 min or 3 min -CGGGCRARGRGGGGGRGCA-5 min The probe may be labelled with a detectable marker, such as an enzyme or biotin, and may be supplied in a diagnostic kit in combination with: a substratum capable of adsorbing DNA or cells, a restriction enzyme, and/or a detergent.</p>
申请公布号 EP0314500(A3) 申请公布日期 1989.07.26
申请号 EP19880310163 申请日期 1988.10.28
申请人 VIRGINIA MASON RESEARCH CENTER 发明人 NEPOM, GERALD T.
分类号 G01N33/50;A61B10/00;C12N15/09;C12Q1/68;(IPC1-7):C12Q1/68 主分类号 G01N33/50
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