HMG-CoA reductase inhibitors

摘要

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) or (II): (I) (II) wherein: n is 1 to 5; R is hydrogen or R1 is hydrogen or methyl; R2 is hydrogen or methyl; and R3 is hydrogen, C1-5 alkyl or C1-5 alkyl substituted with a member of the group consisting of phenyl, dimethylamino, or acetylamino; and the dotted lines at a, b and c represent optional double bonds and pharmaceutically acceptable salts of the compounds (II) in which R3 is hydrogen are disclosed.