5-substituted amino-4-hydroxy-pentanoic acid derivatives and their use

摘要

A 5-substituted amino-4-hydroxy-pentanoic acid derivative having the formula: (I) wherein R1 is a hydrogen atom or an N-protecting group, R2, R3 and R5 may be any of a variety of groups including the side chains of amino acid residues, R4 is a hydrogen atom or a lower alkyl group, R6 is a group which is substituted by one or two hydroxyl groups, and R7 is any of a variety of groups, including a hydroxyl group, which compounds are renin inhibitors useful as hypotensive drugs, are disclosed.