发明名称 Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity
摘要 There are described compounds of formula I, <IMAGE> I in which A is a benzene or heterocyclic ring, y is 0 or 1, L is a group containing 1 or 2 carbon atoms, or is a single bond, R9 and R10 have a variety of significances, e.g. R10 may form part of a double bond with L, or the group -NR9R10 forms a ring carrying substituents R1 and R8, or when L is a single bond -NR10 and R8 may form a ring carrying substituents R16 to R25, or the group -LNR9R10 forms a heterocyclic ring carrying substituents R26 to R33, R1 to R8 and R16 to R33 have a variety of significances n is 0, 1 or 2, x is 3, 4 or 5, X is S, O or NR15, R15 is hydrogen, -COR, -COOR or alkyl optionally substituted by -OCOR, and certain provisos. Processes for making the compounds and pharmaceutical formulations containing them, e.g. for the treatment of conditions involving excess gastric acid secretion, are also described.
申请公布号 US4851419(A) 申请公布日期 1989.07.25
申请号 US19860918832 申请日期 1986.10.14
申请人 FISONS PLC 发明人 COX, DAVID;HALL, DAVID E.;INGALL, ANTHONY H.;SUSCHITZKY, JOHN L.
分类号 C07D235/28;C07D401/12;C07D413/12;C07D417/12 主分类号 C07D235/28
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