摘要 |
Bis-platinum complexes of formula I <CHEM> wherein A is a disubstituted 1,4-anthracenedione; X, X min are ligands selected from the group consisting of Cl, Br, OH, CH3 SOCH3.OH or CH3SOCH3.Hal or, taken together, form the anion of a dicarboxylic acid; m is zero, 0.5 or an integer from 1 to 5; Solv is a solvent of crystallization; Ra is hydrogen, alkyl optionally substituted by hydroxy groups and/or interrupted by oxygen atoms; Rb is alkyl optionally substituted by hydroxy, alkoxy, polyalkoxy or sulphonic groups or a residue of an amino-sugar and n is an integer from 2 to 3. Compounds I are useful as anti-tumor agents. |