FORMYL-METHIONYL CHEMOTATIC PEPTIDE ANTIBIOTIC CONJUGATES USEFUL IN TREATING INFECTIONS

摘要

A group of synthetic N-formyl methionine tri and tetra peptides in covalent combination with antibiotics are useful in treating infections. These peptide-antibiotic conjugates exhibit a high degree of chemotactic activity for polymorphonuclear leukocytes and monocytes while simultaneously inhibiting the growth of microorganisms. The use of chemotactic peptide-silver sulfadiazine conjugates is particularly effective for treating burns.